Investigation of the ectoine gel reparative effect on a thermal burn model
Mots-clés :
Ectoine gel, thermal burn model, counter-anesthesia, skin, histology.Résumé
Due to the ability to create complexes of water molecules on the surface of the mucous membrane, ectoine is a promising compound for the treatment of burns. In male rats (n=30), 2 thermal burns were counteracted under counter-anesthesia, one of which was treated by topical application of the test drugs for 7 days, and the other served as a control. On the 8th day, skin samples in the area of the burn were taken for morphological examination. Histological sections were then scored by independent experts. The best histological picture of thermally damaged tissues was demonstrated by animals receiving ectoine. A less significant, but pronounced reparative effect was observed in histological samples of the actovegin group. The least significant reparative effect was demonstrated by contractubex. Ectoine improved the histological picture, improved repair and reduced the inflammatory response of the tissues and can be recommended for further preclinical studies as a treatment for burns.
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