Peripheral blood parameters as a marker of nonspecific adaptive response of the body in acute infectious diseases with tonsillitis syndrome
Abstract
Evaluation of nonspecific adaptive response of the body in children with acute infectious diseases associated with tonsillitis syndrome was the aim of this research. This prospective study included clinical, anamnestic and laboratory examination of children with acute infectious diseases with tonsillitis syndrome. A systemic multiple factor analysis was conducted (significance level р<0.05). The evaluation of peripheral blood parameters (specific gravity of lymphocytes and indices of reactive protective potential (RPP) - specific immune lymphocytic-monocytic parameter (SILMP) and coefficient of phagocytic defense (CPD)) gives the possibility to determine the condition of nonspecific adaptation in children with acute infectious diseases associated with tonsillitis syndrome. Children with tonsillitis syndrome show significant increase of integral RPP parameters, i.e. decrease of RPP, which is more pronounced on discharge (on admission - in 57% of children, on discharge - in 87%). The most unfavourable initial nonspecific adaptative body response (NABR) (according to the percentage of lymphocytes) is the reaction of increased activation, as it is associated with the transition to the overactivation by the time of discharge (37% of children). Systemic multiple factor analysis determined which peripheral blood parameters have more influence on children’s adaptation during the course of infectious disease: RPP indices showed high influence coefficients in all diseases (CPD was the highest in bacterial infection - Рi 198.3; SILMP was the highest in viral infection - Рi 147.81; in mixed infection CPD and SILMP were roughly the same - Рi – 107.25 and Рi - 78.11, respectively), which proves the feasibility of RPP evaluation for prognostic purposes in the treatment of this category of patients.
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References
Gorban A.N., Tyukina T.A., Smirnova E.V., Pokidysheva L.I. (2016) Evolution of adaptation mechanisms: Adaptation energy, stress, and oscillating death. J Theor Biol. 405: 127-139.
Jones, F., Bright J., Clow A. (2001). Stress: Myth, Theory, and Research. Pearson Education, New York.
Lebedev A.P., Reunova, A.A., Sevastjanova, U.Yu., Kufyak E.V. (2017). Adaptation mechanisms in children with disabilities, KSU Vestnik, 2: 4. (In Russ.)
Pediatrics. National Guidelines, ed. by Baranov A.A., GEOTAR-Media, Moscow 2015. (In Russ.)
Procaccini C, Pucino V, De Rosa V, Marone G, Matarese G. (2014). Neuro-endocrine networks controlling immune system in health and disease. Front Immunol. 5: 143.
Santalova G.V., Gasilina, E.S., Plakhotnikova S.V. (2017). Features of the autonomic nervous system in children with perinatal pathology of the central nervous system, Health and Education in the XXI century, 19: 86-91. (In Russ.).
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