La relación entre los índices hematológicos (PDW, recuento de GB, MPV) en el momento de la admisión y el segmento ST descendente después de la trombolisis en pacientes con infarto de miocardio
Palabras clave:
Índices hematológicos, trombólisis, infarto de miocardio, segmento ST.Resumen
El recuento de glóbulos blancos y el índice de plaquetas (MPV) en el momento de la admisión de los pacientes con STEMI, son los factores predictivos fuertes para los resultados no deseados de los pacientes. El objetivo del presente estudio fue determinar la relación entre los índices hematológicos, incluido el recuento de MPV y WBC en el momento de la admisión de los pacientes con índice de resolución de ST en pacientes con STEMI que fueron tratados con agentes trombolíticos.
En este estudio prospectivo, se tomaron muestras de sangre venosa de 114 pacientes con STEMI para determinar el recuento de PDW, MPV y WBC en el tiempo de referencia de los pacientes y antes de la terapia trombolítica. Según el índice de resolución de ST en 90 minutos después de la terapia trombolítica, los pacientes se clasificaron en dos grupos con resolución de ST inferior al 50% y resolución de ST del 50% o más. Finalmente, los valores de los índices de laboratorio anteriores se compararon entre dos grupos de resolución de ST que este problema se llevó a cabo utilizando el software SPSS versión 21.
Al evaluar a través del análisis de la curva ROC, se determinó que la medición de MPV no se considera como un índice preciso y eficaz para predecir la resolución de ST después de la trombólisis (área bajo la curva: 0.574). El recuento de WBC tampoco fue un indicador aplicable para predecir la resolución de ST después de la trombolisis (Área bajo la curva: 0.660). Finalmente, los resultados del modelo de regresión logística múltiple mostraron que el único predictor de resolución de ST inferior al 50% es el historial de uso de estatinas, de modo que el historial de uso de estatinas aumentó la probabilidad de resolución de ST inferior al 50% en 7 veces (P: 0,028), O: 7.306).
No existe una relación entre la aparición de una resolución completa de ST (más del 50%) y los valores de los índices de MPV y WBC. Por lo tanto, la medición de estos dos indicadores puede no tener la suficiente validez para predecir la resolución del ST después de la trombólisis. Según nuestro estudio, los pacientes con antecedentes de uso de estatinas tienen una prevalencia más baja de resolución completa de ST (más del 50%).
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Andrews, J., Straznicky, I. T., French, J. K., Green, C. L., Maas, A. C., Lund, M., ... & White, H. D. (2000). ST-segment recovery adds to the assessment of TIMI 2 and 3 flow in predicting infarct wall motion after thrombolytic therapy. Circulation, 101(18), 2138-2143.
Antman, E. M., Giugliano, R. P., Gibson, C. M., McCabe, C. H., Coussement, P., Kleiman, N. S., ... & Van der Wieken, R. (1999). Abciximab facilitates the rate and extent of thrombolysis: results of the Thrombolysis in Myocardial Infarction (TIMI) 14 trial. Circulation, 99(21), 2720-2732.
Antman, E. M., Giugliano, R. P., Morrow, D. A., McCabe, C. H., Cutler, S. S., Charlesworth, A., ... & Braunwald, E. (2000). Comparison of a 60-versus 90-minute determination of ST-segment resolution after thrombolytic therapy for acute myocardial infarction. In TIME-II Investigators. Intravenous nPA for Treatment of Infarcting Myocardium Early-II. The American journal of cardiology, 86(11), 1235-7.
Carlsson, J., Kamp, U., Härtel, D., Brockmeier, J., Meierhenrich, R., Miketic, S., ... & Tebbe, U. (1999). Resolution of ST-segment elevation in acute myocardial infarction—Early prognostic significance after thrombolytic therapy. Herz, 24(6), 440-447..
Claeys, M. J., Bosmans, J., Veenstra, L., Jorens, P., De Raedt, H., & Vrints, C. J. (1999). Determinants and prognostic implications of persistent ST-segment elevation after primary angioplasty for acute myocardial infarction: importance of microvascular reperfusion injury on clinical outcome. Circulation, 99(15), 1972-1977.
Darabad, B. R., Vatandust, J., Khoshknab, M. P., & Poorrafsanjani, M. H. (2014). Survey of the effect of opioid abuse on the extent of coronary artery diseases. Global journal of health science, 6(7), 83.
de Lemos, J. A., Antman, E. M., Gibson, C. M., McCabe, C. H., Giugliano, R. P., Murphy, S. A., ... & Van Der Wieken, R. (2000). Abciximab improves both epicardial flow and myocardial reperfusion in ST-elevation myocardial infarction: observations from the TIMI 14 trial. Circulation, 101(3), 239-243.
de Lemos, J. A., Antman, E. M., Giugliano, R. P., Morrow, D. A., McCabe, C. H., Charlesworth, A., ... & Braunwald, E. (2000). Very early risk stratification after thrombolytic therapy with a bedside myoglobin assay and the 12-lead electrocardiogram. American heart journal, 140(3), 373-378.
Dissmann, R., Linderer, T., Goerke, M., von Ameln, H., Rennhak, U., & Schröder, R. (1993). Sudden increase of the ST segment elevation at time of reperfusion predicts extensive infarcts in patients with intravenous thrombolysis. American heart journal, 126(4), 832-839.
Heris, S. O., Rahimi, B., Faridaalaee, G., Hajahmadi, M., Sayyadi, H., & Naghipour, B. (2014). QT dispersion after thrombolytic therapy. International cardiovascular research journal, 8(4), 161.
Huczek, Z., Kochman, J., Filipiak, K. J., Horszczaruk, G. J., Grabowski, M., Piatkowski, R., ... & Opolski, G. (2005). Mean platelet volume on admission predicts impaired reperfusion and long-term mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. Journal of the American College of Cardiology, 46(2), 284-290.
Ito, H., Maruyama, A., Iwakura, K., Takiuchi, S., Masuyama, T., Hori, M., ... & Minamino, T. (1996). Clinical implications of the ‘no reflow’phenomenon: a predictor of complications and left ventricular remodeling in reperfused anterior wall myocardial infarction. Circulation, 93(2), 223-228.
Ito, H., Tomooka, T., Sakai, N., Yu, H., Higashino, Y., Fujii, K., ... & Minamino, T. (1992). Lack of myocardial perfusion immediately after successful thrombolysis. A predictor of poor recovery of left ventricular function in anterior myocardial infarction. Circulation, 85(5), 1699-1705.
Khademvatan, K., Alinejad, V., Eghtedar, S., Rahbar, N., & Agakhani, N. (2014). Survey of the relationship between metabolic syndrome and myocardial infarction in hospitals of Urmia University of medical sciences. Global journal of health science, 6(7), 58.
Khademvatani, K., M. Basiri, V. Alinejad, and M. H. Seyed Mohammad Zad. "Prevalence and correlates of aortic root dilatation in patients with essential hypertension admitted to Seyedoshohada Hospital, Urmia 2012-2013." Journal of Global Pharma Technology 2, no. 8 (2016): 01-06.
Kim, J. S., Kim, J., Choi, D., Lee, C. J., Lee, S. H., Ko, Y. G., ... & Yang, J. Y. (2010). Efficacy of high-dose atorvastatin loading before primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: the STATIN STEMI trial. JACC: Cardiovascular Interventions, 3(3), 332-339.
K?rba?, Ö., Kurmu?, Ö., Köseo?lu, C., Duran Karaduman, B., Saatçi Ya?ar, A., Alemdar, R., ... & Bilge, M. (2014). Association between admission mean platelet volume and ST segment resolution after thrombolytic therapy for acute myocardial infarction. Anadolu Kardiyol Derg, 14(8), 728-732.
Kondo, M., Tamura, K., Tanio, H., & Shimono, Y. (1993). Is ST segment re-elevation associated with reperfusion an indicator of marked myocardial damage after thrombolysis?. Journal of the American College of Cardiology, 21(1), 62-67.
Massberg, S., Schulz, C., & Gawaz, M. (2003). Role of platelets in the pathophysiology of acute coronary syndrome. In Seminars in vascular medicine (Vol. 3, No. 02, pp. 147-162). Copyright© 2003 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.:+ 1 (212) 584-4662.
Matetzky, S., Freimark, D., Chouraqui, P., Novikov, I., Agranat, O., Rabinowitz, B., ... & Hod, H. (1998). The distinction between coronary and myocardial reperfusion after thrombolytic therapy by clinical markers of reperfusion. Journal of the American College of Cardiology, 32(5), 1326-1330.
Matetzky, S., Novikov, M., Gruberg, L., Freimark, D., Feinberg, M., Elian, D., ... & Rabinowitz, B. (1999). The significance of persistent ST elevation versus early resolution of ST segment elevation after primary PTCA. Journal of the American College of Cardiology, 34(7), 1932-1938.
Miida, T., Oda, H., Toeda, T., & Higuma, N. (1994). Additional ST-segment elevation immediately after reperfusion and its effect on myocardial salvage in anterior wall acute myocardial infarction. American Journal of Cardiology, 73(12), 851-855.
Morrow, D. A., Antman, E. M., Charlesworth, A., Cairns, R., Murphy, S. A., de Lemos, J. A., ... & Braunwald, E. (2000). TIMI risk score for ST-elevation myocardial infarction: a convenient, bedside, clinical score for risk assessment at presentation: an intravenous nPA for treatment of infarcting myocardium early II trial substudy. Circulation, 102(17), 2031-2037.
Neumann, F. J., Blasini, R., Schmitt, C., Alt, E., Dirschinger, J., Gawaz, M., ... & Scho?mig, A. (1998). Effect of glycoprotein IIb/IIIa receptor blockade on recovery of coronary flow and left ventricular function after the placement of coronary-artery stents in acute myocardial infarction. Circulation, 98(24), 2695-2701.
Ohman, E. M., Armstrong, P. W., Christenson, R. H., Granger, C. B., Katus, H. A., Hamm, C. W., ... & Califf, R. M. (1996). Cardiac troponin T levels for risk stratification in acute myocardial ischemia. New England Journal of Medicine, 335(18), 1333-1342.
Ohman, E. M., Armstrong, P. W., White, H. D., Granger, C. B., Wilcox, R. G., Weaver, W. D., ... & Topol, E. J. (1999). Risk stratification with a point-of-care cardiac troponin T test in acute myocardial infarction. The American journal of cardiology, 84(11), 1281-1286.
Ohman, E. M., Kleiman, N. S., Gacioch, G., Worley, S. J., Navetta, F. I., Talley, J. D., ... & Miller, M. (1997). Combined accelerated tissue-plasminogen activator and platelet glycoprotein IIb/IIIa integrin receptor blockade with Integrilin in acute myocardial infarction: results of a randomized, placebo-controlled, dose-ranging trial. Circulation, 95(4), 846-854.
Poorrafsanjani, M. H., & Darabad, B. R. (2014). Evaluate the sensitivity and specificity echocardiography in trans-Doppler and tissue Doppler method in the estimation of left ventricular end-diastolic pressure. Global journal of health science, 6(7), 92.
Purcell, I. F., Newall, N., & Farrer, M. (1997). Change in ST segment elevation 60 minutes after thrombolytic initiation predicts clinical outcome as accurately as later electrocardiographic changes. Heart, 78(5), 465-471.
Sabatine, M. S., Morrow, D. A., Cannon, C. P., Murphy, S. A., Demopoulos, L. A., DiBattiste, P. M., ... & Gibson, C. M. (2002). Relationship between baseline white blood cell count and degree of coronary artery disease and mortality in patients with acute coronary syndromes: a TACTICS-TIMI 18 substudy. Journal of the American College of Cardiology, 40(10), 1761-1768.
Saran, R. K., Been, M., Furniss, S. S., Hawkins, T., & Reid, D. S. (1990). Reduction in ST segment elevation after thrombolysis predicts either coronary reperfusion or preservation of left ventricular function. Heart, 64(2), 113-117.
Schröder, R., Dissmann, R., Brüggemann, T., Wegscheider, K., Linderer, T., Tebbe, U., & Neuhaus, K. L. (1994). Extent of early ST segment elevation resolution: a simple but strong predictor of outcome in patients with acute myocardial infarction. Journal of the American College of Cardiology, 24(2), 384-391.
Schröder, R., Wegscheider, K., Schröder, K., Dissmann, R., Meyer-Sabellek, W., & INJECT Trial Group. (1995). Extent of early ST segment elevation resolution: a strong predictor of outcome in patients with acute myocardial infarction and a sensitive measure to compare thrombolytic regimens: a substudy of the International Joint Efficacy Comparison of Thrombolytics (INJECT) trial. Journal of the American College of Cardiology, 26(7), 1657-1664.
Schröder, R., Zeymer, U., Wegscheider, K., & Neuhaus, K. L. (1999). Comparison of the predictive value of ST segment elevation resolution at 90 and 180min after start of streptokinase in acute myocardial infarction. A substudy of the Hirudin for Improvement of Thrombolysis (HIT)-4 Study. European heart journal, 20(21), 1563-1571.
Shah, A., Wagner, G. S., Granger, C. B., O’Connor, C. M., Green, C. L., Trollinger, K. M., ... & Krucoff, M. W. (2000). Prognostic implications of TIMI flow grade in the infarct related artery compared with continuous 12-lead ST-segment resolution analysis: reexamining the “gold standard” for myocardial reperfusion assessment. Journal of the American College of Cardiology, 35(3), 666-672.
Somitsu, Y., Nakamura, M., Degawa, T., & Yamaguchi, T. (1997). Prognostic value of slow resolution of ST-segment elevation following successful direct percutaneous transluminal coronary angioplasty for recovery of left ventricular function. The American journal of cardiology, 80(4), 406-410.
Stubbs, P., Collinson, P., Moseley, D., Greenwood, T., & Noble, M. (1996). Prognostic significance of admission troponin T concentrations in patients with myocardial infarction. Circulation, 94(6), 1291-1297.
Trial of abciximab with and without low-dose reteplase for acute myocardial infarction. (2000). Strategies for Patency Enhancement in the Emergency Department (SPEED) Group. Circulation, 101, 2788-2794.
Vagdatli, E., Gounari, E., Lazaridou, E., Katsibourlia, E., Tsikopoulou, F., & Labrianou, I. (2010). Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia, 14(1), 28.
van der Loo, B., & Martin, J. F. (1999). A role for changes in platelet production in the cause of acute coronary syndromes. Arteriosclerosis, thrombosis, and vascular biology, 19(3), 672-679.
van't Hof, A. W., Liem, A., de Boer, M. J., Zijlstra, F., & Zwolle Myocardial Infarction Study Group. (1997). Clinical value of 12-lead electrocardiogram after successful reperfusion therapy for acute myocardial infarction. The Lancet, 350(9078), 615-619.
Varasteh-Ravan, H. R., Ali-Hassan-Sayegh, S., Shokraneh, S., Mozayan, M. R., & Karimi-bondarabadi, A. A. (2013). Relationship of admission mean platelet volume, platelet distribution width and white blood cells with ST resolution in patients with acute ST segment elevation myocardial infarction treated with streptokinase without history of previous cardiovascular surgery. Perspectives in clinical research, 4(2), 125.
Woo, J. S., Cho, J. M., Kim, S. J., Kim, M. K., & Kim, C. J. (2011). Combined assessments of biochemical markers and ST-segment resolution provide additional prognostic information for patients with ST-segment elevation myocardial infarction. Korean circulation journal, 41(7), 372-378.
Yalcin, A. A., Topuz, M., Akturk, I. F., Celik, O., Erturk, M., Uzun, F., ... & Oner, E. (2015). Is There a Correlation Between Coronary Artery Ectasia and Neutrophil–Lymphocyte Ratio?. Clinical and Applied Thrombosis/Hemostasis, 21(3), 229-234.
Antman, E. M., Giugliano, R. P., Gibson, C. M., McCabe, C. H., Coussement, P., Kleiman, N. S., ... & Van der Wieken, R. (1999). Abciximab facilitates the rate and extent of thrombolysis: results of the Thrombolysis in Myocardial Infarction (TIMI) 14 trial. Circulation, 99(21), 2720-2732.
Antman, E. M., Giugliano, R. P., Morrow, D. A., McCabe, C. H., Cutler, S. S., Charlesworth, A., ... & Braunwald, E. (2000). Comparison of a 60-versus 90-minute determination of ST-segment resolution after thrombolytic therapy for acute myocardial infarction. In TIME-II Investigators. Intravenous nPA for Treatment of Infarcting Myocardium Early-II. The American journal of cardiology, 86(11), 1235-7.
Carlsson, J., Kamp, U., Härtel, D., Brockmeier, J., Meierhenrich, R., Miketic, S., ... & Tebbe, U. (1999). Resolution of ST-segment elevation in acute myocardial infarction—Early prognostic significance after thrombolytic therapy. Herz, 24(6), 440-447..
Claeys, M. J., Bosmans, J., Veenstra, L., Jorens, P., De Raedt, H., & Vrints, C. J. (1999). Determinants and prognostic implications of persistent ST-segment elevation after primary angioplasty for acute myocardial infarction: importance of microvascular reperfusion injury on clinical outcome. Circulation, 99(15), 1972-1977.
Darabad, B. R., Vatandust, J., Khoshknab, M. P., & Poorrafsanjani, M. H. (2014). Survey of the effect of opioid abuse on the extent of coronary artery diseases. Global journal of health science, 6(7), 83.
de Lemos, J. A., Antman, E. M., Gibson, C. M., McCabe, C. H., Giugliano, R. P., Murphy, S. A., ... & Van Der Wieken, R. (2000). Abciximab improves both epicardial flow and myocardial reperfusion in ST-elevation myocardial infarction: observations from the TIMI 14 trial. Circulation, 101(3), 239-243.
de Lemos, J. A., Antman, E. M., Giugliano, R. P., Morrow, D. A., McCabe, C. H., Charlesworth, A., ... & Braunwald, E. (2000). Very early risk stratification after thrombolytic therapy with a bedside myoglobin assay and the 12-lead electrocardiogram. American heart journal, 140(3), 373-378.
Dissmann, R., Linderer, T., Goerke, M., von Ameln, H., Rennhak, U., & Schröder, R. (1993). Sudden increase of the ST segment elevation at time of reperfusion predicts extensive infarcts in patients with intravenous thrombolysis. American heart journal, 126(4), 832-839.
Heris, S. O., Rahimi, B., Faridaalaee, G., Hajahmadi, M., Sayyadi, H., & Naghipour, B. (2014). QT dispersion after thrombolytic therapy. International cardiovascular research journal, 8(4), 161.
Huczek, Z., Kochman, J., Filipiak, K. J., Horszczaruk, G. J., Grabowski, M., Piatkowski, R., ... & Opolski, G. (2005). Mean platelet volume on admission predicts impaired reperfusion and long-term mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. Journal of the American College of Cardiology, 46(2), 284-290.
Ito, H., Maruyama, A., Iwakura, K., Takiuchi, S., Masuyama, T., Hori, M., ... & Minamino, T. (1996). Clinical implications of the ‘no reflow’phenomenon: a predictor of complications and left ventricular remodeling in reperfused anterior wall myocardial infarction. Circulation, 93(2), 223-228.
Ito, H., Tomooka, T., Sakai, N., Yu, H., Higashino, Y., Fujii, K., ... & Minamino, T. (1992). Lack of myocardial perfusion immediately after successful thrombolysis. A predictor of poor recovery of left ventricular function in anterior myocardial infarction. Circulation, 85(5), 1699-1705.
Khademvatan, K., Alinejad, V., Eghtedar, S., Rahbar, N., & Agakhani, N. (2014). Survey of the relationship between metabolic syndrome and myocardial infarction in hospitals of Urmia University of medical sciences. Global journal of health science, 6(7), 58.
Khademvatani, K., M. Basiri, V. Alinejad, and M. H. Seyed Mohammad Zad. "Prevalence and correlates of aortic root dilatation in patients with essential hypertension admitted to Seyedoshohada Hospital, Urmia 2012-2013." Journal of Global Pharma Technology 2, no. 8 (2016): 01-06.
Kim, J. S., Kim, J., Choi, D., Lee, C. J., Lee, S. H., Ko, Y. G., ... & Yang, J. Y. (2010). Efficacy of high-dose atorvastatin loading before primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: the STATIN STEMI trial. JACC: Cardiovascular Interventions, 3(3), 332-339.
K?rba?, Ö., Kurmu?, Ö., Köseo?lu, C., Duran Karaduman, B., Saatçi Ya?ar, A., Alemdar, R., ... & Bilge, M. (2014). Association between admission mean platelet volume and ST segment resolution after thrombolytic therapy for acute myocardial infarction. Anadolu Kardiyol Derg, 14(8), 728-732.
Kondo, M., Tamura, K., Tanio, H., & Shimono, Y. (1993). Is ST segment re-elevation associated with reperfusion an indicator of marked myocardial damage after thrombolysis?. Journal of the American College of Cardiology, 21(1), 62-67.
Massberg, S., Schulz, C., & Gawaz, M. (2003). Role of platelets in the pathophysiology of acute coronary syndrome. In Seminars in vascular medicine (Vol. 3, No. 02, pp. 147-162). Copyright© 2003 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.:+ 1 (212) 584-4662.
Matetzky, S., Freimark, D., Chouraqui, P., Novikov, I., Agranat, O., Rabinowitz, B., ... & Hod, H. (1998). The distinction between coronary and myocardial reperfusion after thrombolytic therapy by clinical markers of reperfusion. Journal of the American College of Cardiology, 32(5), 1326-1330.
Matetzky, S., Novikov, M., Gruberg, L., Freimark, D., Feinberg, M., Elian, D., ... & Rabinowitz, B. (1999). The significance of persistent ST elevation versus early resolution of ST segment elevation after primary PTCA. Journal of the American College of Cardiology, 34(7), 1932-1938.
Miida, T., Oda, H., Toeda, T., & Higuma, N. (1994). Additional ST-segment elevation immediately after reperfusion and its effect on myocardial salvage in anterior wall acute myocardial infarction. American Journal of Cardiology, 73(12), 851-855.
Morrow, D. A., Antman, E. M., Charlesworth, A., Cairns, R., Murphy, S. A., de Lemos, J. A., ... & Braunwald, E. (2000). TIMI risk score for ST-elevation myocardial infarction: a convenient, bedside, clinical score for risk assessment at presentation: an intravenous nPA for treatment of infarcting myocardium early II trial substudy. Circulation, 102(17), 2031-2037.
Neumann, F. J., Blasini, R., Schmitt, C., Alt, E., Dirschinger, J., Gawaz, M., ... & Scho?mig, A. (1998). Effect of glycoprotein IIb/IIIa receptor blockade on recovery of coronary flow and left ventricular function after the placement of coronary-artery stents in acute myocardial infarction. Circulation, 98(24), 2695-2701.
Ohman, E. M., Armstrong, P. W., Christenson, R. H., Granger, C. B., Katus, H. A., Hamm, C. W., ... & Califf, R. M. (1996). Cardiac troponin T levels for risk stratification in acute myocardial ischemia. New England Journal of Medicine, 335(18), 1333-1342.
Ohman, E. M., Armstrong, P. W., White, H. D., Granger, C. B., Wilcox, R. G., Weaver, W. D., ... & Topol, E. J. (1999). Risk stratification with a point-of-care cardiac troponin T test in acute myocardial infarction. The American journal of cardiology, 84(11), 1281-1286.
Ohman, E. M., Kleiman, N. S., Gacioch, G., Worley, S. J., Navetta, F. I., Talley, J. D., ... & Miller, M. (1997). Combined accelerated tissue-plasminogen activator and platelet glycoprotein IIb/IIIa integrin receptor blockade with Integrilin in acute myocardial infarction: results of a randomized, placebo-controlled, dose-ranging trial. Circulation, 95(4), 846-854.
Poorrafsanjani, M. H., & Darabad, B. R. (2014). Evaluate the sensitivity and specificity echocardiography in trans-Doppler and tissue Doppler method in the estimation of left ventricular end-diastolic pressure. Global journal of health science, 6(7), 92.
Purcell, I. F., Newall, N., & Farrer, M. (1997). Change in ST segment elevation 60 minutes after thrombolytic initiation predicts clinical outcome as accurately as later electrocardiographic changes. Heart, 78(5), 465-471.
Sabatine, M. S., Morrow, D. A., Cannon, C. P., Murphy, S. A., Demopoulos, L. A., DiBattiste, P. M., ... & Gibson, C. M. (2002). Relationship between baseline white blood cell count and degree of coronary artery disease and mortality in patients with acute coronary syndromes: a TACTICS-TIMI 18 substudy. Journal of the American College of Cardiology, 40(10), 1761-1768.
Saran, R. K., Been, M., Furniss, S. S., Hawkins, T., & Reid, D. S. (1990). Reduction in ST segment elevation after thrombolysis predicts either coronary reperfusion or preservation of left ventricular function. Heart, 64(2), 113-117.
Schröder, R., Dissmann, R., Brüggemann, T., Wegscheider, K., Linderer, T., Tebbe, U., & Neuhaus, K. L. (1994). Extent of early ST segment elevation resolution: a simple but strong predictor of outcome in patients with acute myocardial infarction. Journal of the American College of Cardiology, 24(2), 384-391.
Schröder, R., Wegscheider, K., Schröder, K., Dissmann, R., Meyer-Sabellek, W., & INJECT Trial Group. (1995). Extent of early ST segment elevation resolution: a strong predictor of outcome in patients with acute myocardial infarction and a sensitive measure to compare thrombolytic regimens: a substudy of the International Joint Efficacy Comparison of Thrombolytics (INJECT) trial. Journal of the American College of Cardiology, 26(7), 1657-1664.
Schröder, R., Zeymer, U., Wegscheider, K., & Neuhaus, K. L. (1999). Comparison of the predictive value of ST segment elevation resolution at 90 and 180min after start of streptokinase in acute myocardial infarction. A substudy of the Hirudin for Improvement of Thrombolysis (HIT)-4 Study. European heart journal, 20(21), 1563-1571.
Shah, A., Wagner, G. S., Granger, C. B., O’Connor, C. M., Green, C. L., Trollinger, K. M., ... & Krucoff, M. W. (2000). Prognostic implications of TIMI flow grade in the infarct related artery compared with continuous 12-lead ST-segment resolution analysis: reexamining the “gold standard” for myocardial reperfusion assessment. Journal of the American College of Cardiology, 35(3), 666-672.
Somitsu, Y., Nakamura, M., Degawa, T., & Yamaguchi, T. (1997). Prognostic value of slow resolution of ST-segment elevation following successful direct percutaneous transluminal coronary angioplasty for recovery of left ventricular function. The American journal of cardiology, 80(4), 406-410.
Stubbs, P., Collinson, P., Moseley, D., Greenwood, T., & Noble, M. (1996). Prognostic significance of admission troponin T concentrations in patients with myocardial infarction. Circulation, 94(6), 1291-1297.
Trial of abciximab with and without low-dose reteplase for acute myocardial infarction. (2000). Strategies for Patency Enhancement in the Emergency Department (SPEED) Group. Circulation, 101, 2788-2794.
Vagdatli, E., Gounari, E., Lazaridou, E., Katsibourlia, E., Tsikopoulou, F., & Labrianou, I. (2010). Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia, 14(1), 28.
van der Loo, B., & Martin, J. F. (1999). A role for changes in platelet production in the cause of acute coronary syndromes. Arteriosclerosis, thrombosis, and vascular biology, 19(3), 672-679.
van't Hof, A. W., Liem, A., de Boer, M. J., Zijlstra, F., & Zwolle Myocardial Infarction Study Group. (1997). Clinical value of 12-lead electrocardiogram after successful reperfusion therapy for acute myocardial infarction. The Lancet, 350(9078), 615-619.
Varasteh-Ravan, H. R., Ali-Hassan-Sayegh, S., Shokraneh, S., Mozayan, M. R., & Karimi-bondarabadi, A. A. (2013). Relationship of admission mean platelet volume, platelet distribution width and white blood cells with ST resolution in patients with acute ST segment elevation myocardial infarction treated with streptokinase without history of previous cardiovascular surgery. Perspectives in clinical research, 4(2), 125.
Woo, J. S., Cho, J. M., Kim, S. J., Kim, M. K., & Kim, C. J. (2011). Combined assessments of biochemical markers and ST-segment resolution provide additional prognostic information for patients with ST-segment elevation myocardial infarction. Korean circulation journal, 41(7), 372-378.
Yalcin, A. A., Topuz, M., Akturk, I. F., Celik, O., Erturk, M., Uzun, F., ... & Oner, E. (2015). Is There a Correlation Between Coronary Artery Ectasia and Neutrophil–Lymphocyte Ratio?. Clinical and Applied Thrombosis/Hemostasis, 21(3), 229-234.
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2019-02-27
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Raberi, V. S., Ezati, E., & Zadeh, R. F. (2019). La relación entre los índices hematológicos (PDW, recuento de GB, MPV) en el momento de la admisión y el segmento ST descendente después de la trombolisis en pacientes con infarto de miocardio. Amazonia Investiga, 8(18), 139–149. Recuperado a partir de https://amazoniainvestiga.info/index.php/amazonia/article/view/290
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