Circulating markers of vascular damage as predictors of cardiovascular events in atherosclerosis and metabolic disorders

A. A. Tarasov; A. R. Babaeva; M. A. Osadchuk; V. A. Reshetnikov; N. P. Korzhenkov; K. S. Solodenkova; M. V. Trushin

A. A. Tarasov Volgograd State Medical University, Pavshikh Bortsov Sq., Russia
A. R. Babaeva Volgograd State Medical University, Pavshikh Bortsov Sq., Russia
M. A. Osadchuk I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
V. A. Reshetnikov I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
N. P. Korzhenkov I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
K. S. Solodenkova I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
M. V. Trushin Kazan Federal University, Kazan, Russia

Keywords: Endothelial dysfunction, immune inflammation, cytokines, autoantibodies, atherosclerosis, ischemic heart disease, coronary artery disease, diabetes mellitus, metabolic syndrome.

Abstract

The article presents the results of cluster analysis of the contribution of immune inflammation and endothelial dysfunction (ED) markers to the frequency and severity of cardiovascular events (CVE) in cohorts of patients with asymptomatic atherosclerosis (AAS), coronary artery disease (CAD), type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS) during a 3-year prospective observation.

Results Circulating markers of ED and immune inflammation, such as ET-1, IL-1β, TNF-α, antibodies to collagen type I and III, and antibodies to chondroitine sulfate (CS) contribute to cardiovascular (CV) manifestation in AAS. In CAD patients ET-1, eNOs, antibodies to collagen, as well as IL-6 and vWf are the main contributors. In T2DM without clinical manifestation of CAD, the set of markers associated with the adverse events includes ET-1, eNOs, IL-6, anti-C, and anti-HA. In CAD combined with T2DM, the cluster of markers associated with the adverse events includes vWf, TNF-α, eNOs, IL-6, anti-C, anti-HA and CRP. In AAS without MS, the key contributors are ET-1 and vWf, and the presence of anti-C and anti-ChS; in AAS/MS patients, the key markers are IL-1β, TNF-α, anti-C, anti-ChS, anti-HA, and CRP. In CAD without MS, the cluster of markers associated with adverse events includes ET-1, eNOs and anti-HA; in CAD/MS it includes anti-C, ET-1, and IL-6.

Conclusion. The obtained results confirm the role of systemic inflammation in the development of atherosclerosis-associated angiopathy in coronary pathology and disorders of carbohydrate metabolism, and also suggest a set of circulating markers as predictors of adverse CVE.

Downloads

Download data is not yet available.

Author Biographies

A. A. Tarasov, Volgograd State Medical University, Pavshikh Bortsov Sq., Russia

Volgograd State Medical University, Pavshikh Bortsov Sq., Russia

A. R. Babaeva, Volgograd State Medical University, Pavshikh Bortsov Sq., Russia

Volgograd State Medical University, Pavshikh Bortsov Sq., Russia

M. A. Osadchuk, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

V. A. Reshetnikov, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

N. P. Korzhenkov, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

K. S. Solodenkova, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

M. V. Trushin, Kazan Federal University, Kazan, Russia

Kazan Federal University, Kazan, Russia

References

Algorithms of specialized medical care for patients with diabetes mellitus, clinical guidelines, 8th edition. // Diabetes. 2017; 20 (1S): 1-112. DOI: 10.14341 / DM20171S8.

Boytsov SA, Kukharchuk VV, Karpov YA. Subclinical atherosclerosis as a risk factor for cardiovascular events. Cardiovascular therapy and prevention, 2012, 11 (3): 82-86.
Kaptoge S, Seshasai SR, Gao P, Freitag DF, Butterworth AS, Borglykke A. Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis. European Heart Journal, 2014, 35(9): 578–589.

Libby P., Crea F. Clinical implications of inflammation for cardiovascular primary prevention. European Heart Journal, 2010, 31(7): 777–783.

Mueller Ch. Biomarkers and acute coronary syndromes: an update. European Heart Journal, 2014, 35(9): 552-556.

Ridker PM. Targeting inflammatory pathways for the treatment of cardiovascular disease. European Heart Journal, 2014, 35(9): 540-543.
de Rooij S. R., Nijpels G., Nilsson P. M.. Low-grade chronic inflammation in the relationship between insulin sensitivity and cardiovascular disease (RISC) population: associations with insulin resistance and cardiometabolic risk profile. Diabetes Care, 2009, 32(7): 1295–1301.

Russian Statistical Yearbook 2017. Moscow, 2017. P.85-110.ISBN 978-5-89476-440-5. Publisher of the Federal State Statistics Service, 2017.

Svistunov AA, Babaeva AR, Osadchuk MA, Gordeeva MA, Tarasov AA, Davidov SI, Shulkina SG, Trushin MV Markers of Immune Inflammation in the Diagnosis of Coronary Complications // J. Pharm. Sci. & Res., 2018, 10(9): 2269-2272.

Tarasov AA, Babaeva AR, Gordeeva MA, Reznikova EA. Clinical and prognostic value of vascular wall lesion pathogenic markers in asymptomatic atherosclerosis. Medical alphabet, 2017, 3(13): 28-34.

Tarasov AA, Reznikova EA, Davydov SI, Bochkaryova OI, Babaeva AR. Clinical and prognostic value of endothelial dysfunction markers in atherosclerosis-associated vascular lesions. Medical alphabet, 2016, 3(30): 5-11.